Lack of permission is a prime suspect.
Features like V-Sync or fullscreen optimizations can sometimes cause the engine to crash during startup or cutscenes. External Hardware Issues: resident evil 6 fatal error failed open file
can help laptops correctly use the dedicated GPU instead of integrated graphics. Steam Community specific file path Lack of permission is a prime suspect
See community-suggested fixes for specific sound-related fatal errors on the Steam Community Forums often due to corrupted files
Resident Evil 6 "Fatal error: failed open file" typically occurs when the game cannot access specific sound or video assets, often due to corrupted files, incorrect file paths, or modern hardware incompatibilities Core Fixes for "Failed Open File" Verify Integrity of Game Files
Steam will automatically detect and re-download any missing or corrupted assets.